Resistance to chemotherapy is typically associated with poor outcomes for patients with cancer. However, St. Jude Children's Research Hospital scientists demonstrated that in bilateral Wilms tumor (cancer in both kidneys) ...
Mar 28, 2024
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A team of researchers led by Associate Professor Makoto Ikeya (Department of Clinical Application) has observed early signs of success from providing iPSC-derived mesenchymal stem/stromal cells (iMSCs) instructions to produce ...
Mar 27, 2024
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Tumor mutation burden (TMB) is considered an important predictive biomarker for the efficacy of immunotherapy. However, in cancer types where TMB is not positively correlated with the abundance of CD8+ T cells, TMB cannot ...
Mar 19, 2024
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The tumor microenvironment (TME) is the ecosystem surrounding a tumor, which usually consists of non-tumoral cells and molecules they produce and release. The interplay between tumor cells and the TME significantly impacts ...
Mar 4, 2024
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Osteoarthritis (OA) is a debilitating joint disease which affects over 500 million people worldwide, with trends increasing as populations age. OA is caused by progressive, irreversible degeneration of joint cartilage, leading ...
Feb 29, 2024
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A new research paper titled "Prognostic significance of senescence-related tumor microenvironment genes in head and neck squamous cell carcinoma" has been published in Aging.
Jan 31, 2024
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A combination of two cancer drugs could be effective against malignant peripheral nerve sheath tumors (MPNSTs)—soft tissue tumors that are stubbornly resistant to chemotherapy and radiation—according to a laboratory study ...
Jan 31, 2024
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Non-cancerous cells called stromal cells, which are found in and around prostate tumors, may be useful in assessing these tumors' potential to spread, and may even be targets for future prostate cancer treatments, according ...
Jan 18, 2024
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Before a drug can be used to treat a disease, it must go through a lengthy and expensive trial process to prove both safety and effectiveness. By repurposing already-approved drugs, researchers can cut out the time and expense ...
Jan 12, 2024
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New Cleveland Clinic research reveals how BRCA1 and BRCA2 gene mutations may impact cell communication in breast tissue, furthering the understanding of how cancer develops.
Nov 13, 2023
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