Oncology & Cancer

Team discovers broken 'brake' of cancer mutation machine

Loss of a gene known as SYNCRIP in prostate cancer tumors unleashes cellular machinery that creates random mutations throughout the genome that drive resistance to targeted treatments, a team led by UT Southwestern Medical ...

Diseases, Conditions, Syndromes

How hepatitis E tricks the immune system

Over 3 million people are infected with the hepatitis E virus every year. So far, no effective treatment is available. An international team has investigated which factors are important for the virus in the course of its ...

Diseases, Conditions, Syndromes

We are mutating SARS-CoV-2, but it is evolving back

Scientists investigating the evolution of the virus that causes COVID-19 say that its mutation seems to be directed by human proteins that degrade it, but natural selection of the virus enables it to bounce back. The findings ...

Diseases, Conditions, Syndromes

Leprosy's drug resistance and origin revealed by genome analysis

Leprosy is an infectious disease with gruesome symptoms. It damages the skin, peripheral nerves, the upper respiratory tract, and the eyes. Despite being curable with multidrug therapy, leprosy still persists in many developing ...

Medical research

Tezacaftor-ivacaftor, ivacaftor alone effective in CF

(HealthDay)—Tezacaftor-ivacaftor or ivacaftor alone is effective for patients with cystic fibrosis who are heterozygous for the Phe508del deletion, and tezacaftor-ivacaftor is effective for patients who are homozygous for ...

Genetics

Will unanticipated genetic mutations lead to subsequent disease?

A study published Nov. 9 in the journal Science Translational Medicine is the first to show that mutations in certain cancer and cardiovascular genes put individuals at an increased risk for dominantly inherited, actionable ...

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