Unraveling the genetic puzzle of Alzheimer's disease
As Australia's population ages, we're hearing a growing number of stories about complex diseases with cognitive and behavioral effects.
Jan 18, 2024
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As Australia's population ages, we're hearing a growing number of stories about complex diseases with cognitive and behavioral effects.
Jan 18, 2024
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34
An analysis of a large Swedish cohort revealed that breast density, microcalcifications, and masses are heritable features, and that breast density and microcalcifications were positively associated with a genetic predisposition ...
Apr 2, 2020
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Although long life tends to run in families, genetics has far less influence on life span than previously thought, according to a new analysis of an aggregated set of family trees of more than 400 million people. The results ...
Nov 6, 2018
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When you go to the doctor or hospital, one piece of information that you're always asked to provide—in addition to your name, address, and insurance information—is an emergency contact. Often, that person is a blood relative. ...
May 17, 2018
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In the largest study of twins in schizophrenia research to date, researchers at the University of Copenhagen, Denmark, estimate that as much as 79% of schizophrenia risk may be explained by genetic factors. The estimate indicates ...
Oct 5, 2017
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Reanalysis of data from a previous study on the familial risk of autism spectrum disorder (ASD) estimates the heritability to be 83 percent, suggesting that genetic factors may explain most of the risk for ASD, according ...
Sep 26, 2017
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The National Academy of Sciences and National Academy of Medicine issued a 258-page report Tuesday (Feb. 14) focused on human genome editing. It lays out principles and recommendations for the U.S. government and governments ...
Feb 14, 2017
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A new study of twins suggests that insomnia in adults is partially explained by genetic factors, and this heritability is higher in females than in males.
Sep 16, 2015
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Despite a strong suspected link between genetics and asthma, commonly found genetic mutations account for only a small part of the risk for developing the disease - a problem known as missing heritability.
Jan 16, 2015
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New research, led by King's College London finds that the high heritability of exam grades reflects many genetically influenced traits such as personality, behaviour problems, and self-efficacy and not just intelligence.
Oct 6, 2014
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Heritability is the proportion of phenotypic variation in a population that is due to genetic variation between individuals. Phenotypic variation among individuals may be due to genetic, environmental factors, and/or random chance. Heritability analyzes the relative contributions of differences in genetic and non-genetic factors to the total phenotypic variance in a population. It is measured by estimating the relative contributions of genetic and non-genetic differences to the total phenotypic variation in a population. Heritability is an important concept in quantitative genetics, particularly in selective breeding and behaviour genetics (for instance twin studies), but is less widely used in population genetics.
Heritability measures the fraction of phenotype variability that can be attributed to genetic variation. This is not the same as saying that this fraction of an individual phenotype is caused by genetics. In addition, heritability can change without any genetic change occurring. For example, if both genes and environment have the potential to influence intelligence, but if a given sample of individuals shows very little genetic variation and a great deal of environmental variation, then the contribution of genetic variability to phenotype variability in that sample will be lower than if the sample showed greater genetic variability. Because of this it can be seen that heritability is specific to a particular population in a particular environment.
The extent of dependence of phenotype on environment can also be function of the genes involved. Genes may canalize a phenotype, making its expression almost inevitable in all occurring environments. Individuals with the same genotype can exhibit different phenotypes through a mechanism called phenotypic plasticity, which makes heritability difficult to measure in some cases. Recent insights in molecular biology have identified changes in transcriptional activity of individual genes associated with environmental changes. However, there are a large number of genes whose transcription is not affected by the environment.
This text uses material from Wikipedia, licensed under CC BY-SA