Heparin, the world's most widely used blood thinner, is used during procedures ranging from kidney dialysis to open heart surgery. Currently, heparin is derived from pig intestines, but scientists at Rensselaer Polytechnic ...
Mar 18, 2024
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A medication commonly prescribed to pregnant women with an inheritable blood clotting condition and a history of recurrent miscarriage does not help to reduce their miscarriage risk, a new international study led by UK researchers ...
May 30, 2023
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Heparin has long been used as a blood thinner, or anticoagulant, for patients with blood clotting disorders or after surgery to prevent complications. But the medication remains difficult to dose correctly, potentially leading ...
Jan 6, 2023
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Newly published research out of the University of Cincinnati and the University of California-Davis shows that direct oral anticoagulant (DOAC) drugs are more effective and are more cost-effective than low molecular weight ...
Jan 4, 2023
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Bivalirudin is a safer and more effective anticoagulant than heparin for treating patients with the most serious type of heart attacks who undergo urgent percutaneous coronary intervention (PCI), and can lower the risk of ...
Nov 7, 2022
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An international team of scientists has discovered a molecule that prevents tumor cells spreading from a primary cancer site to colonize other sites in the body.
Jul 25, 2022
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A large-scale study is the first to evaluate blood viscosity in the prediction of mortality in COVID-19 patients. A simple calculation of blood viscosity was more robust in the identification of hospitalized patients at risk ...
Jul 18, 2022
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A research team led by Prof. Dr. Tamam Bakchoul from the Institute for Clinical and Experimental Transfusion Medicine (IKET) at the University Hospital of Tübingen is investigating the suitability of anticoagulants in patients ...
Jun 23, 2022
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The most expensive part of the pig is neither the tenderloin nor the neck chop, but part of the intestine used for medicine against blood clots. There are about 2,000 pigs required to produce a kilogram of the drug heparin, ...
Feb 23, 2022
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Heparin, a widely available and affordable drug, has found to limit lung damage when inhaled by COVID-19 patients.
Jan 21, 2022
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Heparin (from Ancient Greek ηπαρ (hepar), liver), also known as unfractionated heparin, a highly sulfated glycosaminoglycan, is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. It can also be used to form an inner anticoagulant surface on various experimental and medical devices such as test tubes and renal dialysis machines.
Although it is used principally in medicine for anticoagulation, its true physiological role in the body remains unclear, because blood anti-coagulation is achieved mostly by heparan sulfate proteoglycans derived from endothelial cells. Heparin is usually stored within the secretory granules of mast cells and released only into the vasculature at sites of tissue injury. It has been proposed that, rather than anticoagulation, the main purpose of heparin is defense at such sites against invading bacteria and other foreign materials. In addition, it is conserved across a number of widely different species, including some invertebrates that do not have a similar blood coagulation system.
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